01
Mood · motivation · connection
Depression
Research spans established dissociative treatment and experimental classic-psychedelic approaches. The evidence and experience differ substantially by medicine.
Conditions & questions · 07 pathsStart with
Start with
the why.
Sometimes the medicine is the starting point. Sometimes it is grief, pain, trauma, habit, disconnection, or the hope that life could feel different.
This map shows associations and research questions—not treatment recommendations.A medicine appears here because it is part of current research, established clinical practice in a specific context, or sustained public interest. That does not mean it is approved for the condition—or a good fit for every person.
02
Fear · uncertainty · serious illness
Anxiety & distress
Studies often focus on anxiety linked to depression, serious illness, or existential distress rather than treating every kind of anxiety as one category.
CONNECTED MEDICINES
Psilocybin
Classic psychedelic↗LSD
Classic psychedelic↗03
Trauma · memory · therapeutic support
PTSD
The most developed psychedelic-adjacent research centers on MDMA-assisted therapy, where the medicine and structured therapeutic process are studied together.
CONNECTED MEDICINES
MDMA
Entactogen↗04
Connection · safety · belonging
Social anxiety
Small and early studies have explored whether entactogenic effects may support work with social fear in specific populations.
CONNECTED MEDICINES
MDMA
Entactogen↗05
Pain · perception · nervous system
Chronic pain
Ketamine is used clinically in some pain settings, while protocols, evidence quality, access, and suitability vary by pain condition.
CONNECTED MEDICINES
Ketamine
Dissociative↗06
Habit · craving · behavior change
Alcohol-use disorder
Psilocybin and LSD have both been studied alongside structured psychological support, with different eras and strengths of evidence.
CONNECTED MEDICINES
Psilocybin
Classic psychedelic↗LSD
Classic psychedelic↗07
Dependence · withdrawal · recovery
Opioid-use disorder & addiction
Ibogaine attracts significant interest and personal testimony, but evidence remains preliminary and cardiac risk makes this a particularly high-stakes area.
CONNECTED MEDICINES
Ibogaine
Psychoactive alkaloid↗The question behind the question matters.
Diagnosis labels are only one layer. Intent, expectations, culture, support, medications, physical health, previous experiences, and what happens afterward can matter just as much to the shape of an experience.